Chrysin loaded nanostructured lipid carriers (NLCs) triggers apoptosis in MCF-7 cancer cells by inhibiting the Nrf2 pathway
作者： Mehdi Sabzichi , Jamal Mohammadian , Roya Bazzaz , Mohammad Bagher Pirouzpanah , Maghsod Shaaker
DOI: 10.1016/J.PROCBIO.2017.05.024
关键词:
摘要: Abstract We investigated the role of chrysin as an effective adjuvant along with nanostructured lipid carriers (NLCs) to increase cytotoxicity doxorubicin (Dox) in MCF-7 breast cancer cells. The prepared formulation was characterized from point view scanning electron microscope (SEM), size & zeta potential. Cellular uptake and nanoparticles were examined by fluorescent microscopy MTT assay, respectively. Flow cytometry real-time PCR used understand molecular mechanism Nrf2 related downregulating genes. average 105 ± 2 nm, which confirmed SEM. Our results demonstrated that incubation cells chrysin-loaded NLCs enhanced percentage apoptosis 21.11 ± 5.72% 27 ± 3.13% (p
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