Pathways involved in acetaminophen hepatotoxicity with specific targets for inhibition/downregulation

摘要: The liver, a vital organ in our body, is highly prone to numerous diseases/disorders. most prolific among the extensive array of liver disorders and challenging clinical/pharmaceutical industries drug-induced hepatotoxicity. Acetaminophen (APAP), recommended as first-line analgesic therapy prescribed an over-the-counter (OTC) medication, possesses excellent safety profile when administered therapeutic dosages, but hepatotoxicity can occur overdosed during misuse/combinational therapy, that be disastrous. It well recognized pathogenesis APAP induced involves contribution parent drug/its metabolites [NAPQI (N-acetyl-p-benzoquinone imine)] directly and/or indirectly modulate bioenergetics cells through various metabolic disturbances immune reactions. In spite many recent scientific reports which have established key signal transduction pathways, streaming events involved this mechanism are not easily monitored, profound impact research. compiling research perspectives, review, flow chronological hepatotoxicity, its molecular pathways triggered immunological responses been elucidated. This information provides strong hypothetical rationale create vivid picture regarding underlying disease thereby establish new prophylactic/therapeutic interventions by targeting few specific targets, also from signalling pathways. brief, review constructs/establishes molecular/immunological aspects based on advancements area.