Clinical and Microbiological Aspects of β-Lactam Resistance in Staphylococcus lugdunensis.

摘要: Antimicrobial susceptibility results from broth microdilution MIC testing of 993 Staphylococcus lugdunensis isolates recovered patients at a tertiary care medical center 2008 to 2015 were reviewed. Ninety-two oxacillin-susceptible selected assess the accuracy penicillin testing, disk diffusion test, and three β-lactamase tests, including cefoxitin-induced nitrocefin cloverleaf assay, zone edge test. The all phenotypic tests compared blaZ PCR. records 62 whom S. was isolated, 31 penicillin-susceptible penicillin-resistant strains, retrospectively reviewed evaluate clinical significance isolation, antimicrobial agents prescribed, if any, outcome. revealed that 517/993 (52.1%) susceptible 946/993 (95.3%) oxacillin. induced test 100% sensitive specific for detection PCR results, whereas showed sensitivities but specificities only 9.1% 89.1%, respectively. had categorical agreement with PCR, while yielded one major error. Only 3/31 treated family antimicrobial. majority cases other β-lactams, trimethoprim-sulfamethoxazole, or vancomycin. These data indicate nearly are narrow-spectrum agents. Clinical laboratories in areas resistance levels similar those described here can help promote use these versus vancomycin by effectively designing their reports convey this message.