A concise route to virginiamycin M2.

作者: Qi Li , Ian B. Seiple

DOI: 10.1016/J.TET.2019.04.060

关键词:

摘要: Modular, fully synthetic routes to structurally complex natural products provide useful avenues access chemical diversity. Herein we report a concise route virginiamycin M2, member of the group A streptogramin class that inhibits bacterial protein synthesis. Our approach features longest linear sequence six steps from 7 simple building blocks, and is shortest highest yielding synthesis any reported date. We believe this will enable unexplored structural diversity may serve as tool improve therapeutic potential antibiotics.

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