摘要: Modular, fully synthetic routes to structurally complex natural products provide useful avenues access chemical diversity. Herein we report a concise route virginiamycin M2, member of the group A streptogramin class that inhibits bacterial protein synthesis. Our approach features longest linear sequence six steps from 7 simple building blocks, and is shortest highest yielding synthesis any reported date. We believe this will enable unexplored structural diversity may serve as tool improve therapeutic potential antibiotics.