Insights into the relation between mRNA and protein expression patterns: I. Theoretical considerations.

摘要: Translation is a central cellular process in every organism and understanding translation from the systems (genome-wide) perspective very important for medical biochemical engineering applications. Moreover, recent advances cell-wide monitoring tools both mRNA protein levels have necessitated development of such model to identify parameters conditions that influence mapping between expression. Experimental studies show lack correspondence expression profiles. In this study, we describe mechanistic genome-wide provides changes levels. We use our study system detail key affect mapping. Our results correlation function kinetic concentration ribosomes at reference state. particular, free total response perturbation; initiation elongation kinetics due competition aminoacyl tRNAs; termination kinetics; average stability are all determinants