Nifedipine therapy for stable angina pectoris: preliminary results of effects on angina frequency and treadmill exercise response.

摘要: Ten patients with stable angina pectoris secondary to atherosclerotic coronary artery disease received nifedipine (10 mg and 20 orally three times daily, each for 2 weeks) or placebo (for in a single-blind manner during 6 week period. One patient was excluded because nocturnal resting developed while he receiving placebo. The frequency of anginal attacks the remaining nine decreased from 11.2 ± 2.2 (mean standard error mean) per administration 7.1 1.6 therapy at 10 6.3 ±1.7 (P < 0.05 both doses active drug versus placebo). Nitroglycerin consumption similarly 8.9 2.3 tablets (placebo) 4.8 1.4 4.2 1.2 Duration treadmill exercise increased 368 50 seconds 471 72 dose 522 79 Maximal S-T segment shift product heart rate × systolic blood pressure did not differ between period that therapy. Treadmill performed subsequent double-blind, randomized crossover treatment revealed duration after (524 49 seconds) compared (462 52 0.005) but, again, maximal differ. Side effects were minor easily tolerable. results seem indicate prolongs time by decreasing given work load, possibly similar long-acting nitrate