摘要: Nuclear factor κB (NF-κB) is a family of major transcription factors that play various important roles under physiological and pathological conditions. NF-κB are ubiquitously expressed, including neurons glial cells the central nervous system (CNS). The in CNS, both as mediators transcriptional response to synaptic activity behavioral paradigms learning memory, focus recent studies. In this chapter, general structure, functions, regulation signaling first described concisely. Advances made understanding CNS brain diseases then reviewed more detail. pathway potential therapeutic target discussed at end.
springer.com
sci-hub.st 参考文章(157)
Robert H. Lipsky, Ke Xu, Daming Zhu, Charles Kelly, Artin Terhakopian, Antonello Novelli, Ann M. Marini, Nuclear factor κB is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection Journal of Neurochemistry. ,vol. 78, pp. 254- 264 ,(2001) , 10.1046/J.1471-4159.2001.00386.X
Ashok Kumar, Yasunari Takada, AladinM. Boriek, BharatB. Aggarwal, Nuclear factor-κB: its role in health and disease Journal of Molecular Medicine. ,vol. 82, pp. 434- 448 ,(2004) , 10.1007/S00109-004-0555-Y
E. C. Beattie, Control of Synaptic Strength by Glial TNFalpha Science. ,vol. 295, pp. 2282- 2285 ,(2002) , 10.1126/SCIENCE.1067859
Armin Schneider, Ana Martin-Villalba, Falk Weih, Johannes Vogel, Thomas Wirth, Markus Schwaninger, NF-κB is activated and promotes cell death in focal cerebral ischemia Nature Medicine. ,vol. 5, pp. 554- 559 ,(1999) , 10.1038/8432
Alexander Ravati, Barbara Ahlemeyer, Andreas Becker, Susanne Klumpp, Josef Krieglstein, Preconditioning‐induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor‐κB Journal of Neurochemistry. ,vol. 78, pp. 909- 919 ,(2001) , 10.1046/J.1471-4159.2001.00463.X
Amy S. Weinmann, Deborah M. Mitchell, Shomyseh Sanjabi, Michelle N. Bradley, Alexander Hoffmann, Hsiou-Chi Liou, Stephen T. Smale, Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event. Nature Immunology. ,vol. 2, pp. 51- 57 ,(2001) , 10.1038/83168
Marty W. Mayo, Jacqueline L. Norris, Albert S. Baldwin, Ras regulation of NF-KB and apoptosis Methods in Enzymology. ,vol. 333, pp. 73- 87 ,(2001) , 10.1016/S0076-6879(01)33046-X
Asok Mukhopadhyay, Sunil K. Manna, Bharat B. Aggarwal, Pervanadate-induced Nuclear Factor-κB Activation Requires Tyrosine Phosphorylation and Degradation of IκBα COMPARISON WITH TUMOR NECROSIS FACTOR-α Journal of Biological Chemistry. ,vol. 275, pp. 8549- 8555 ,(2000) , 10.1074/JBC.275.12.8549
Asha L. Bhakar, Laura-Lee Tannis, Christine Zeindler, Maria Pia Russo, Christian Jobin, David S. Park, Sandra MacPherson, Philip A. Barker, Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival The Journal of Neuroscience. ,vol. 22, pp. 8466- 8475 ,(2002) , 10.1523/JNEUROSCI.22-19-08466.2002
A. A. Beg, D. Baltimore, An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death Science. ,vol. 274, pp. 782- 784 ,(1996) , 10.1126/SCIENCE.274.5288.782