Levodopa-induced psychosis: a kindling phenomenon.

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DOI: 10.1176/AJP.135.6.669

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摘要: Of 88 patients with idiopathic Parkinson's disease, without prior psychotic symptoms, and significant dementia, nearly half had experienced vivid dreams, hallucinations, illusions, nonconfusional as well confusional psychoses side effects of chronic levodopa therapy within the previous year treatment. It was found that 61.3% all hallucinations were associated preexistent or concurrent dream phenomena, states dreams and/or tended to become confusional. These findings raise possibility may result in dopaminergic kindling support hypothesis agonism may, via such a mechanism, play role development some types psychoses.

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