Mitochondrial biology in cancer stem cells.
作者： Rute Loureiro , Katia A. Mesquita , Silvia Magalhães-Novais , Paulo J. Oliveira , Ignacio Vega-Naredo
DOI: 10.1016/J.SEMCANCER.2017.06.012
关键词:
摘要: Cancer stem cells (CSCs) have been suggested to be responsible for tumor re-growth and relapse. Physiological morphological knowledge of CSCs may essential the development new therapeutic strategies targeting cancer development, progression, recurrence. Current research is focused on a deeper understanding metabolic profiles, taking into consideration their energy demands. Energy metabolism mitochondrial function are important factors operating stemness maintenance cell fate specification. Due role mitochondria as central hubs in overall death survival pathways, physiology paramount importance decipher mechanisms underlying therapy-resistant phenotype. In this review, we focus biology mitochondria-related signaling pathways that contribute maintenance, thereby representing possible targets.
mpg.de
core.ac.uk 
sci-hub.se 参考文章(227)
Si-Zhao Lu, Duygu Dee Harrison-Findik, Autophagy and cancer. World Journal of Biological Chemistry. ,vol. 4, pp. 64- 70 ,(2013) , 10.4331/WJBC.V4.I3.64
Erik Ames, Robert J. Canter, Steven K. Grossenbacher, Stephanie Mac, Mingyi Chen, Rachel C. Smith, Takeshi Hagino, Jessica Perez-Cunningham, Gail D. Sckisel, Shiro Urayama, Arta M. Monjazeb, Ruben C. Fragoso, Thomas J. Sayers, William J. Murphy, NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype Journal of Immunology. ,vol. 195, pp. 4010- 4019 ,(2015) , 10.4049/JIMMUNOL.1500447
Weiguo Feng, Andrew Gentles, Ramesh V. Nair, Min Huang, Yuan Lin, Cleo Y. Lee, Shang Cai, Ferenc A. Scheeren, Angera H. Kuo, Maximilian Diehn, Targeting unique metabolic properties of breast tumor initiating cells Stem Cells. ,vol. 32, pp. 1734- 1745 ,(2014) , 10.1002/STEM.1662
Georg Oberhuber, Peter Birner, Gerhard Breitenecker, Monika Schindl, Andreas Obermair, Christina Plank, Overexpression of Hypoxia-inducible Factor 1α Is a Marker for an Unfavorable Prognosis in Early-Stage Invasive Cervical Cancer Cancer Research. ,vol. 60, pp. 4693- 4696 ,(2000)
Qingshan Chang, Bailing Chen, Chitra Thakur, Yongju Lu, Fei Chen, Arsenic-induced sub-lethal stress reprograms human bronchial epithelial cells to CD61¯ cancer stem cells Oncotarget. ,vol. 5, pp. 1290- 1303 ,(2014) , 10.18632/ONCOTARGET.1789
Li Liu, Pei Fan, Yiyao Zhang, Jury Gladkich, Clifford C. Nwaeburu, Jürgen Mattern, Martin Mollenhauer, Felix Rückert, Sebastian Zach, Uwe Haberkorn, Wolfgang Gross, Frank Schönsiegel, Alexandr V. Bazhin, Ingrid Herr, Orkhan Isayev, Vanessa Rausch, Nathalie Bauer, Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine Oncotarget. ,vol. 5, pp. 5177- 5189 ,(2014) , 10.18632/ONCOTARGET.2120
Anna Pastò, Chiara Bellio, Giorgia Pilotto, Vincenzo Ciminale, Micol Silic-Benussi, Giulia Guzzo, Andrea Rasola, Chiara Frasson, Giorgia Nardo, Elisabetta Zulato, Maria Ornella Nicoletto, Mariangela Manicone, Stefano Indraccolo, Alberto Amadori, Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation Oncotarget. ,vol. 5, pp. 4305- 4319 ,(2014) , 10.18632/ONCOTARGET.2010
Wei-Hsiu Liu, Ming-Teh Chen, Mong-Lien Wang, Yi-Yen Lee, Guang-Yuh Chiou, Chian-Shiu Chien, Pin-I Huang, Yi-Wei Chen, Ming-Chao Huang, Shih-Hwa Chiou, Yang-Hsin Shih, Hsin-I Ma, None, Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells. Oncotarget. ,vol. 6, pp. 1750- 1768 ,(2015) , 10.18632/ONCOTARGET.2737
Antonella Managò, Luigi Leanza, Luca Carraretto, Nicola Sassi, SILVIA Grancara, Ruben Quintana-Cabrera, Valentina Trimarco, Antonio Toninello, Luca Scorrano, Livio Trentin, G Semenzato, E Gulbins, Mario Zoratti, Ildiko' Szabo, Early effects of the antineoplastic agent salinomycin on mitochondrial function. Cell Death and Disease. ,vol. 6, ,(2015) , 10.1038/CDDIS.2015.263
Wenyu Zhou, Michael Choi, Daciana Margineantu, Lilyana Margaretha, Jennifer Hesson, Christopher Cavanaugh, C Anthony Blau, Marshall S Horwitz, David Hockenbery, Carol Ware, Hannele Ruohola-Baker, HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC‐to‐EpiSC/hESC transition The EMBO Journal. ,vol. 31, pp. 2103- 2116 ,(2012) , 10.1038/EMBOJ.2012.71