Methods of diagnosis or detection using three-dimensional analysis

作者: Sabine Mai , Soumya Panigrahi , Alice Chuang , Bartholomeus Vermolen , William Foulkes

DOI:

关键词:

摘要: The invention provides methods of diagnosing or detecting hereditary breast cancer versus non-hereditary cancer. In particular, the relates to cells that have mutant BRCA1 BRCA2 genes as compared wild type and genes. also using 3D analysis genetic analysis. characterizing telomeric organization a cell genetically analyzing for presence translocation, deletion amplification. addition, simultaneously protein nuclear structures

参考文章(5)
José Ignacio Martín-Subero, Ilse Chudoba, Lana Harder, Stefan Gesk, Werner Grote, Francisco Javier Novo, María José Calasanz, Reiner Siebert, Multicolor-FICTION: expanding the possibilities of combined morphologic, immunophenotypic, and genetic single cell analyses. American Journal of Pathology. ,vol. 161, pp. 413- 420 ,(2002) , 10.1016/S0002-9440(10)64197-1
S Henderson, R Allsopp, D Spector, S S Wang, C Harley, In situ analysis of changes in telomere size during replicative aging and cell transformation Journal of Cell Biology. ,vol. 134, pp. 1- 12 ,(1996) , 10.1083/JCB.134.1.1
Tony Chuang, Sharareh Moshir, Yuval Garini, Alice Chuang, Ian T Young, Bart Vermolen, Richard van den Doel, Virginie Mougey, Mathilde Perrin, Martina Braun, Paul Kerr, Thierry Fest, Petra Boukamp, Sabine Mai, The three-dimensional organization of telomeres in the nucleus of mammalian cells BMC Biology. ,vol. 2, pp. 12- 12 ,(2004) , 10.1186/1741-7007-2-12
Hank W. Bass, Wallace F. Marshall, John W. Sedat, David A. Agard, W. Zacheus Cande, Telomeres Cluster De Novo before the Initiation of Synapsis: A Three-dimensional Spatial Analysis of Telomere Positions before and during Meiotic Prophase Journal of Cell Biology. ,vol. 137, pp. 5- 18 ,(1997) , 10.1083/JCB.137.1.5
Yuval Garini, Sabine Mai, Sharareh Moshir, Bartholomeus J. Vermolen, Tony Chih Yuan Chuang, Method of monitoring genomic instability using 3d microscopy and analysis ,(2004)