摘要: This review outlines the chemistry and anticancer cytotoxic properties of certain Mannich bases. It is divided into four parts. The first section summarizes briefly various investigations undertaken by other researchers chemical pharmacological a number bases against neoplasms. remaining portions this are summaries work in laboratory. second part presents following aspects namely differences antileukemic activity between conjugated styryl ketones related bases, intramolecular cyclization acyclic effect on such process, prodrug approaches with view to obtaining preferential toxicity cancerous rather than normal cells finally antineoplastic introducing basic centre these compounds. third promising vitro activities different which effective WiDr human colon cancer preparation group drug resistant malignant cells. evidence for evaluations theory proposed one authors called sequential cytotoxicity presented followed description very high some 4-piperidones; compounds may be regarded as cyclic Finally , biochemical outlined especially reference their causing inhibition respiration mitochondria, particularly those organelles obtained from neoplastic tissue