The phosphoinositide signaling cycle in myelin requires cooperative interaction with the axon

摘要: Previous studies on the origin of myelin phosphoinositides involved in signaling mechanisms indicated axon to transfer phosphatidylinositol followed by myelin-localized incorporation axon-derived phosphate groups into 4-monophosphate and 4,5-bisphosphate. This is agreement with other showing presence phosphorylating activity that converts mono-and diphospho derivatives. It was also found second messenger, inositol 1,4,5-trisphosphate, hydrolyzed 1,4-bisphosphate a enzyme. The present study undertaken determine locus remaining reactions leading formation free completion cycle resynthesis phosphatidylinositol. latter reaction occur preferentially isolated axons, limited extent if at all myelin. On hand, hydrolytic which sequentially convert 1,4,5-trisphosphate 1,4-bisphosphate, 1-phosphate, were more prominently Thus, restoration following signal-induced breakdown PIP2 seen as requiring metabolic interplay between axon.