A longitudinal study of hair cortisol concentrations in Macaca nemestrina mothers and infants.

摘要: Cortisol is a well-known glucocorticoid that can be used as biomarker of hypothalamic-pituitary-adrenocortical activity. To explore basal cortisol physiology during pregnancy and infancy in Macaca nemestrina monkeys, hair was collected from convenience sample 22 healthy mother–infant dyads. Adult females were housed pairs part small breeding colony at the Washington National Primate Research Center infants reared specialized nursery. Maternal samples pregnancy-detection ultrasound immediately following labor delivery. Infant birth, 20 days, 4, 6, 8, 10 months age. Hair concentrations (HCCs) determined using an enzyme immunoassay washed ground samples. Like human mothers, macaque HCCs rose (paired t = 5.8, df = 16, P < 0.001). (114.2 ± 12.07 picogram/milligram [pg/mg]) highly predictive maternal delivery (144.8 ± 13.60 pg/mg), suggesting trait-like quality (r = 0.90, When viewed on continuum, absolute rise over course significantly related to newborn (r = 0.55, P = 0.02). birth (1,027.43 ± 97.95 pg/mg) seven times higher than t = 19.1, Higher strongly associated with larger decreases infant until 6 postnatal age when converged values indistinguishable adults. Overall, study results demonstrate marked degree fetal exposure latter gestation suggest may play influential role newborn.