Deregulation of Mitochondrial Function: A Potential Common Theme for Cardiovascular Disease Development

摘要: The pathogenesis of atherosclerosis has been intensively studied and described; yet, despite these advances, the underlying events that initiate athero-genesis are not yet fully understood. Consequently, cardiovascular disease remains major cause death morbidity in western world. Although studies general agreement is a chronic, inflammatory disease, additionally, increased oxidative stress plays key factor early stages development, impact such changes on subcellular or organellar components their functions relevant to inception less appreciated. In this regard, beginning show mitochondria common targets they may play significant roles regulation cell function. A theme among risk factors can mediate mitochondrial damage dysfunction, moreover, significantly increase for onset. Moreover, it recently suggested balance between energy efficiency, oxidant production, thermogenesis developed during human prehistory long-term implications susceptibility, evolution disease. Hence, emphasis review discussion unique features functional biology potentially make central focal point terms mechanistic basis