CD33 modulates TREM2: convergence of Alzheimer loci

作者: Gail Chan , Charles C White , Phoebe A Winn , Maria Cimpean , Joseph M Replogle

DOI: 10.1038/NN.4126

关键词:

摘要: … of CD33 and TREM2 are linked and that TREM2 may lie … TREM2, we examined the relationship between TREM2 and AD pathology in ROS-MAP data and found that increased TREM2 …

参考文章(27)
Joseph M. Replogle, Gail Chan, Charles C. White, Towfique Raj, Phoebe A. Winn, Denis A. Evans, Reisa A. Sperling, Lori B. Chibnik, Elizabeth M. Bradshaw, Julie A. Schneider, David A. Bennett, Philip L. De Jager, A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. Annals of Neurology. ,vol. 77, pp. 469- 477 ,(2015) , 10.1002/ANA.24337
A. Mildner, B. Schlevogt, K. Kierdorf, C. Bottcher, D. Erny, M. P. Kummer, M. Quinn, W. Bruck, I. Bechmann, M. T. Heneka, J. Priller, M. Prinz, Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease The Journal of Neuroscience. ,vol. 31, pp. 11159- 11171 ,(2011) , 10.1523/JNEUROSCI.6209-10.2011
Adam C Naj, Gyungah Jun, Gary W Beecham, Li-San Wang, Badri Narayan Vardarajan, Jacqueline Buros, Paul J Gallins, Joseph D Buxbaum, Gail P Jarvik, Paul K Crane, Eric B Larson, Thomas D Bird, Bradley F Boeve, Neill R Graff-Radford, Philip L De Jager, Denis Evans, Julie A Schneider, Minerva M Carrasquillo, Nilufer Ertekin-Taner, Steven G Younkin, Carlos Cruchaga, John S K Kauwe, Petra Nowotny, Patricia Kramer, John Hardy, Matthew J Huentelman, Amanda J Myers, Michael M Barmada, F Yesim Demirci, Clinton T Baldwin, Robert C Green, Ekaterina Rogaeva, Peter St George-Hyslop, Steven E Arnold, Robert Barber, Thomas Beach, Eileen H Bigio, James D Bowen, Adam Boxer, James R Burke, Nigel J Cairns, Chris S Carlson, Regina M Carney, Steven L Carroll, Helena C Chui, David G Clark, Jason Corneveaux, Carl W Cotman, Jeffrey L Cummings, Charles DeCarli, Steven T DeKosky, Ramon Diaz-Arrastia, Malcolm Dick, Dennis W Dickson, William G Ellis, Kelley M Faber, Kenneth B Fallon, Martin R Farlow, Steven Ferris, Matthew P Frosch, Douglas R Galasko, Mary Ganguli, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Sid Gilman, Bruno Giordani, Jonathan D Glass, John H Growdon, Ronald L Hamilton, Lindy E Harrell, Elizabeth Head, Lawrence S Honig, Christine M Hulette, Bradley T Hyman, Gregory A Jicha, Lee-Way Jin, Nancy Johnson, Jason Karlawish, Anna Karydas, Jeffrey A Kaye, Ronald Kim, Edward H Koo, Neil W Kowall, James J Lah, Allan I Levey, Andrew P Lieberman, Oscar L Lopez, Wendy J Mack, Daniel C Marson, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, Joseph E Parisi, Daniel P Perl, Elaine Peskind, Ronald C Petersen, Wayne W Poon, Joseph F Quinn, Ruchita A Rajbhandary, Murray Raskind, Barry Reisberg, John M Ringman, Erik D Roberson, Roger N Rosenberg, Mary Sano, Lon S Schneider, William Seeley, Michael L Shelanski, Michael A Slifer, Charles D Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Rudolph E Tanzi, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Jennifer Williamson, Randall L Woltjer, Laura B Cantwell, Beth A Dombroski, Duane Beekly, Kathryn L Lunetta, Eden R Martin, M Ilyas Kamboh, Andrew J Saykin, Eric M Reiman, David A Bennett, John C Morris, Thomas J Montine, Alison M Goate, Deborah Blacker, Debby W Tsuang, Hakon Hakonarson, Walter A Kukull, Tatiana M Foroud, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Common variants at MS4A4/MS4A6E , CD2AP , CD33 and EPHA1 are associated with late-onset Alzheimer's disease Nature Genetics. ,vol. 43, pp. 436- 443 ,(2011) , 10.1038/NG.801
G. Kleinberger, Y. Yamanishi, M. Suarez-Calvet, E. Czirr, E. Lohmann, E. Cuyvers, H. Struyfs, N. Pettkus, A. Wenninger-Weinzierl, F. Mazaheri, S. Tahirovic, A. Lleo, D. Alcolea, J. Fortea, M. Willem, S. Lammich, J. L. Molinuevo, R. Sanchez-Valle, A. Antonell, A. Ramirez, M. T. Heneka, K. Sleegers, J. van der Zee, J.-J. Martin, S. Engelborghs, A. Demirtas-Tatlidede, H. Zetterberg, C. Van Broeckhoven, H. Gurvit, T. Wyss-Coray, J. Hardy, M. Colonna, C. Haass, TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science Translational Medicine. ,vol. 6, ,(2014) , 10.1126/SCITRANSLMED.3009093
Yaming Wang, Marina Cella, Kaitlin Mallinson, Jason D Ulrich, Katherine L Young, Michelle L Robinette, Susan Gilfillan, Gokul M Krishnan, Shwetha Sudhakar, Bernd H Zinselmeyer, David M Holtzman, John R Cirrito, Marco Colonna, TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model Cell. ,vol. 160, pp. 1061- 1071 ,(2015) , 10.1016/J.CELL.2015.01.049
Philip L De Jager, Joshua M Shulman, Lori B Chibnik, Brendan T Keenan, Towfique Raj, Robert S Wilson, Lei Yu, Sue E Leurgans, Dong Tran, Cristin Aubin, Christopher D Anderson, Alessandro Biffi, Jason J Corneveaux, Matthew J Huentelman, Jonathan Rosand, Mark J Daly, Amanda J Myers, Eric M Reiman, David A Bennett, Denis A Evans, None, A genome-wide scan for common variants affecting the rate of age-related cognitive decline Neurobiology of Aging. ,vol. 33, pp. 1017- ,(2012) , 10.1016/J.NEUROBIOLAGING.2011.09.033
Bin Zhang, Chris Gaiteri, Liviu-Gabriel Bodea, Zhi Wang, Joshua McElwee, Alexei A. Podtelezhnikov, Chunsheng Zhang, Tao Xie, Linh Tran, Radu Dobrin, Eugene Fluder, Bruce Clurman, Stacey Melquist, Manikandan Narayanan, Christine Suver, Hardik Shah, Milind Mahajan, Tammy Gillis, Jayalakshmi Mysore, Marcy E. MacDonald, John R. Lamb, David A. Bennett, Cliona Molony, David J. Stone, Vilmundur Gudnason, Amanda J. Myers, Eric E. Schadt, Harald Neumann, Jun Zhu, Valur Emilsson, Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease Cell. ,vol. 153, pp. 707- 720 ,(2013) , 10.1016/J.CELL.2013.03.030
Fr�d�ric Lajaunias, Jean-Michel Dayer, Carlo Chizzolini, Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling. European Journal of Immunology. ,vol. 35, pp. 243- 251 ,(2005) , 10.1002/EJI.200425273
CY Daniel Lee, Gary E Landreth, None, The role of microglia in amyloid clearance from the AD brain. Journal of Neural Transmission. ,vol. 117, pp. 949- 960 ,(2010) , 10.1007/S00702-010-0433-4
Quan Yuan, Changbiao Chu, Jianping Jia, Association studies of 19 candidate SNPs with sporadic Alzheimer’s disease in the North Chinese Han population Neurological Sciences. ,vol. 33, pp. 1021- 1028 ,(2012) , 10.1007/S10072-011-0881-0