作者: William A. Stini
DOI: 10.1146/ANNUREV.AN.24.100195.002145
关键词:
摘要: Osteoporosis is a condition in which loss of bone density leads to increased risk fracture. This increasing frequency most parts the world and has become major cause medical expenditures United States, where it estimated cost nearly $10 billion per year. European countries report similar increases proportion their costs attributable osteoporosis. In cases, osteoporosis, occurs earlier more frequently women, associated with age-related endocrine changes, especially decline estrogen production occurring at menopause. However, occurrence resulting from factors such as inactivity, low peak early adulthood, calcium intake, variety dietary lifestyle can lead high fracture before because continual state turnover, balance between formation resorption be upset by number endogenous exogenous factors. R...