The SPARC Score: A Multifactorial Outcome Prediction Model for Patients Undergoing Radical Cystectomy for Bladder Cancer

摘要: Purpose: While multiple independent clinicopathological variables are associated with the outcome of radical cystectomy for bladder cancer, limited prediction tools exist to facilitate individualized risk assessment. We developed SPARC (Survival Prediction After Radical Cystectomy) score, a model cancer specific survival after cystectomy.Materials and Methods: evaluated 2,403 patients who underwent without neoadjuvant therapy at our institution between 1980 2008 pathological re-review all specimens. Of these 1,776 nonmetastatic urothelial carcinoma were identified analysis. A multivariate was using stepwise selection determine survival. created scoring system based on β coefficients this model.Results: Median followup in alive last 10.5 years (IQR 7.3, 15.3), during which time 610 had died bladde...