Association between aminolevulinate dehydrogenase genotype and blood lead levels in Taiwan.
作者： Ling-Ling Hsieh , Saou-Hsing Liou , Yeong-Hwang Chen , Li-Chun Tsai , Tsann Yang
DOI: 10.1097/00043764-200002000-00009
关键词:
摘要: This study was designed to evaluate the association between aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels in a general population environmentally exposed lead. of 660 subjects secondarily sampled from 3000 random samples Taiwanese distribution population. A simple assay based on polymerase chain reaction-restriction fragment length polymorphism technique used determine ALAD gene. found that most 1-1 (95.4%). Only 4.6% (30 subjects) were be 1-2 or 2-2. It has been hypothesized ALAD2 allele is associated with increased absorption individuals alleles had 20% higher than persons ALAD1 (7.83 +/- 5.95 vs 6.51 5.03 micrograms/dL). However, difference not statistically significant, even after adjustment for other risk factors environmental exposure. The result supports previous finding levels. small sample size large amount variation our may account insignificant association.
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sci-hub.st 参考文章(11)
James G. Wetmur, G. Lehnert, Robert J. Desnick, The δ-aminolevulinate dehydratase polymorphism: Higher blood lead levels in lead workers and environmentally exposed children with the 1–2 and 2-2 isozymes Environmental Research. ,vol. 56, pp. 109- 119 ,(1991) , 10.1016/S0013-9351(05)80001-5
Ewa Raczek, Polymorphism of delta-aminolevulinate dehydratase in the upper Silesian population, Poland. Human Heredity. ,vol. 44, pp. 172- 174 ,(1994) , 10.1159/000154211
Heide-G. Benkmann, Petra Bogdanski, Werner Goedde, Polymorphism of delta-aminolevulinic acid dehydratase in various populations. Human Heredity. ,vol. 33, pp. 62- 64 ,(1983) , 10.1159/000153351
R. Petrucci, A. Leonardi, G. Battistuzzi, The genetic polymorphism of delta-aminolevulinate dehydrase in Italy. Human Genetics. ,vol. 60, pp. 289- 290 ,(1982) , 10.1007/BF00303023
Saou-Hsing LIOU, Guang-Yang YANG, Trong-Neng WU, Ying-Chin KO, Ching-Chang LEE, Shien-Tsong HO, Jim-Shoung LAI, Yea-Quay WU, Horn-Che CHIANG, Kquei-Nu KO, Po-Ya CHANG, Assessment of Interlaboratory Performance on the Measurement of Blood Lead Levels in Taiwanese Adults Industrial Health. ,vol. 33, pp. 181- 190 ,(1995) , 10.2486/INDHEALTH.33.181
M. Berode, V. Wietlisbach, M. Rickenbach, M.P. Guillemin, Lifestyle and environmental factors as determinants of blood lead levels in a Swiss population Environmental Research. ,vol. 55, pp. 1- 17 ,(1991) , 10.1016/S0013-9351(05)80136-7
James L. Pirkle, The Decline in Blood Lead Levels in the United States JAMA. ,vol. 272, pp. 284- 291 ,(1994) , 10.1001/JAMA.1994.03520040046039
Saou-Hsing Liou, Trong-Neng Wu, Horn-Che Chiang, Guang-Yang Yang, Tsann Yang, Yea-Quay Wu, Jim-Shoung Lai, Shien-Tsong Ho, Ching-Chang Lee, Ying-Chin Ko, Kquei-Nu Ko, Po-Ya Chang, Blood lead levels in Taiwanese adults: Distribution and influencing factors Science of The Total Environment. ,vol. 180, pp. 211- 219 ,(1996) , 10.1016/0048-9697(96)80245-2
Saou-Hsing Liou, Trong-Neng Wu, Horn-Che Chiang, Guang-Yang Yang, Yea-Quay Wu, Jim-Shoung Lai, Shien-Tsong Ho, Yue-Liang Guo, Ying-Chin Ko, Po-Ya Chang, Blood lead levels in the general population of Taiwan, Republic of China. International Archives of Occupational and Environmental Health. ,vol. 66, pp. 255- 260 ,(1994) , 10.1007/BF00454364
Angelo Bortoli, Giorgio Fazzin, Valeria Marin, Gianfranco Trabuio, Sergio Zotti, Relationships between Blood Lead Concentration and Aminolevulinic Acid Dehydratase in Alcoholics and Workers Industrially Exposed to Lead Archives of Environmental Health. ,vol. 41, pp. 251- 260 ,(1986) , 10.1080/00039896.1986.9938341