Striatal firing rate reflects head movement velocity

摘要: Although the basal ganglia have long been implicated in initiation of actions, their contribution to movement remains a matter dispute. Using wireless multi-electrode recording and motion tracking, we examined relationship between single-unit activity sensorimotor striatum kinematics. We recorded from medium spiny projection neurons fast-spiking interneurons while monitoring movements mice using tracking. In Experiment 1, trained generate reliably by water-depriving them giving periodic cued sucrose rewards. found high correlations velocity particular directions. This correlation was both putative interneurons. 2, rule out possibility that observed were due reward expectancy, repeated same procedure but added trials which delivery replaced an aversive air puff stimulus. The generated avoidance clearly different on rewarded trials, showed exhibited similar trials. These experiments show for first time firing rate striatal reflects types movements, whether seek rewards or avoid harm.