Atherogenesis and Coronary Heart Disease

摘要: There are two major pathways by which atherosclerosis progresses: excess lipids in blood, end up atherosclerotic plaque, and inflammatory forces. Much recent research has demonstrated the association of chronic low-level inflammation (microinflammation) with both diabetes cardiovascular disease. It appears that microinflammation is not only a result these diseases but also exhibits “positive feedback,” causing disease process to accelerate. This downward spiral slope modified genetic architecture environmental variables, may prove difficult interrupt or modify effectively, since involved represent pathophysiology normal homeostatic physiology. We currently have some medications do seem work this process, such as aspirin statins. The role environment clearly important, now emerging. need for more effective public health efforts education behavior modification, well economic political approaches arrest burgeoning global epidemic obesity. already know if lipid burden decreased, will decrease. If we can understand microinflammatory enough detail, learn how activities, be able decrease through mechanism well, affect development other old age. By attacking arms finally limit progressive atherosclerosis, possibly age well. Keywords: diabetes; insulin resistance; inflammation; hemostasis; fibrinolysis; atherosclerosis; cardiovascular