Evaluation of antiproliferative effects of the somatostatin analogue somatuline in a rabbit model of traction retinal detachment.

摘要: As growth hormone (GH) and insulin-like factor type I (IGF-I) have been suggested to be involved in the development of some proliferative ocular disorders, we investigated eventual antiproliferative properties a long acting somatostatin analogue, somatuline or BIM23014 (IPSEN Biotech, France), an original model experimental vitreoretinopathy. Two studies were separately done investigate respective effects subcutaneously- intravitreally administered somatuline. Injections 10 7 human platelets freshly prepared from unique normal donor injected into vitreous, cavity pigmented rabbits. The first experiment consisted evaluating vitreoretinal proliferation 17 eyes rabbits receiving subcutaneous injections 25 μg/kg BIM23014, given twice day, day after injection for one month. A group 14 served as non treated controls. second was conducted 33 : received 1 μg once week month, similarly 5 μg/week somatuline, remaining 13 serving controls with intravitreal sterile saline. All animals examined ophthalmoscopically month masked manner, sacrificed at end histological immunohistological analyses. In all but two subcutaneously group, preretinal membranes formed, five eight days platelet injection. Intravitreal progressively increased, resulting various degrees retraction retinal detachment. Finally, comparison between control showed significantly fewer detachments ones (7/17 vs 11/14, p < 0.05) lower scores (3.79 ± 1.25 2.24 1.78, = 0.01). contrast, comparisons untreated no difference, nor protective effect intraocular Histological examination revealed groups lymphocytes keratin- vimentin-positive cells forming pattems retraction. thus significant reduction proliferation, only when systemically. These results suggest therapeutic interest retinopathies, additional will necessary better understand role GH, IGF-I these disorders.