Peripheral blood dendritic cells in children with acute Plasmodium falciparum malaria
作者： Britta C. Urban , Tabitha Mwangi , Amanda Ross , Samson Kinyanjui , Moses Mosobo
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摘要: The importance of dendritic cells (DCs) for the initiation and regulation immune responses not only to foreign organisms but also self has raised considerable interest in qualitative quantitative analysis these various human diseases. Plasmodium falciparum malaria is characterized by poor induction long-lasting protective responses. This study, therefore, investigated percentage peripheral blood DCs as lineage marker-negative HLA-DR(+) or CD83(+) healthy children suffering from acute Kilifi, Kenya. Comparable percentages were found with malaria. However, was significantly reduced results suggest that a proportion may be functionally impaired due low expression HLA-DR on their surface.
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Thibaut De Smedt, Bernard Pajak, Eric Muraille, Jacques Urbain, Oberdan Leo, Muriel Moser, Positive and Negative Regulation of Dendritic Cell Function by Lipopolysaccharide in Vivo Advances in Experimental Medicine and Biology. ,vol. 417, pp. 535- 540 ,(1997) , 10.1007/978-1-4757-9966-8_88
D.B. Fearnley, L.F. Whyte, S.A. Carnoutsos, A.H. Cook, D.N.J. Hart, Monitoring Human Blood Dendritic Cell Numbers in Normal Individuals and in Stem Cell Transplantation Blood. ,vol. 93, pp. 728- 736 ,(1999) , 10.1182/BLOOD.V93.2.728
Sunetra Gupta, Robert W. Snow, Christl A. Donnelly, Kevin Marsh, Chris Newbold, Immunity to non-cerebral severe malaria is acquired after one or two infections. Nature Medicine. ,vol. 5, pp. 340- 343 ,(1999) , 10.1038/6560
Marina Cella, Fabio Facchetti, Antonio Lanzavecchia, Marco Colonna, Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization. Nature Immunology. ,vol. 1, pp. 305- 310 ,(2000) , 10.1038/79747
Marina Cella, David Jarrossay, Fabio Facchetti, Olga Alebardi, Hideo Nakajima, Antonio Lanzavecchia, Marco Colonna, Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nature Medicine. ,vol. 5, pp. 919- 923 ,(1999) , 10.1038/11360
H Giha, L Hviid, I M Elhassan, C Roper, J S McBride, A A Holder, D R Cavanagh, V J Robinson, D E Arnot, T G Theander, A Longitudinal Study of Type-Specific Antibody Responses to Plasmodium falciparum Merozoite Surface Protein-1 in an Area of Unstable Malaria in Sudan Journal of Immunology. ,vol. 161, pp. 347- 359 ,(1998)
Britta C. Urban, David J. P. Ferguson, Arnab Pain, Nick Willcox, Magdalena Plebanski, Jonathan M. Austyn, David J. Roberts, Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells. Nature. ,vol. 400, pp. 73- 77 ,(1999) , 10.1038/21900
T. F. Tedder, Liang-Ji Zhou, Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. Journal of Immunology. ,vol. 154, pp. 3821- 3835 ,(1995)
Steven Patterson, Stephen P Robinson, Nicholas R English, Stella C Knight, Subpopulations of peripheral blood dendritic cells show differential susceptibility to infection with a lymphotropic strain of HIV-1 Immunology Letters. ,vol. 66, pp. 111- 116 ,(1999) , 10.1016/S0165-2478(98)00166-7
B.M. Greenwood, A.K. Bradley, I.S. Blakebrough, H.C. Whittle, T.F. de C. Marshall, H.M. Gilles, The immune response to a meningococcal polysaccharide vaccine in an African village. Transactions of The Royal Society of Tropical Medicine and Hygiene. ,vol. 74, pp. 340- 346 ,(1980) , 10.1016/0035-9203(80)90095-4