Mouse models illuminate MAIT cell biology.

摘要: The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification vitamin-B-based antigens recognised by these specialised cells. Over past few years, our understanding complexities MAIT function developed, as they find their place among other better known cells immune system. Key questions relate to when help, hinder or cause harm, and do not matter. Exploiting mouse strains that differ in numbers, leveraged specific detection using MR1-tetramers, it now been shown play important roles settings include bacterial viral infections, autoimmune diseases cancer. We have also learnt much about development, modes activation response commensal microbiota, begun try ways manipulate improve disease outcomes. Here we review recent studies assessed models disease.