Biochemical Pharmacology of Sleep

作者: Rafael de Jesus Cabeza , Rebecca K. Zoltoski , J. Christian Gillin

DOI: 10.1016/B978-0-7506-9002-7.50009-4

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摘要: Publisher Summary This chapter describes the biochemical pharmacology of sleep. Various theoretical models have been proposed to account for regulation sleep and wakefulness. One model that takes into both circadian homeostatic considerations is two-process developed by Borbely associates. The first, process S, a process—the longer organism awake, greater will be its propensity more intense second, C, reflects an oscillatory determines threshold sensitivity factor thus affects waking. Process C hypothesized entrain or entrained with other oscillators responsible biologic rhythms, such as temperature, cortisol secretion, rapid eye movement (REM) current widely accepted paradigm REM promoted cholinergic neurons originate in brain stem, most probably lateral dorsal tegmental nucleus pedunculopontine group, it inhibited noradrenergic serotonergic located locus ceruleus raphe, respectively. Cholinergic exert widespread crucial role orchestration sleep, through their projections medial pontine reticular formation, medulla, forebrain areas thalamus basal forebrain.

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