Extracellular Vesicles (EVs) and Pancreatic Cancer: From the Role of EVs to the Interference with EV-Mediated Reciprocal Communication
作者： Sokviseth Moeng , Seung Wan Son , Jong Sun Lee , Han Yeoung Lee , Tae Hee Kim
DOI: 10.3390/BIOMEDICINES8080267
关键词:
摘要: Pancreatic cancer is malignant and the seventh leading cause of cancer-related deaths worldwide. However, chemotherapy radiotherapy are-at most-moderately effective, indicating need for new different kinds therapies to manage this disease. It has been proposed that biologic properties pancreatic cells are finely tuned by dynamic microenvironment, which includes extracellular matrix, cancer-associated cells, diverse immune cells. Accumulating evidence demonstrated vesicles (EVs) play an essential role in communication between heterogeneous subpopulations transmitting multiplex biomolecules. EV-mediated cell-cell ultimately contributes several aspects cancer, such as growth, angiogenesis, metastasis therapeutic resistance. In review, we discuss their cargo molecules cancer. We also present feasibility inhibition biosynthesis itinerary (release uptake) a attractive strategy against
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