Well-defined diblock glycopolymers from RAFT polymerization in homogeneous aqueous medium

摘要: Reversible addition−fragmentation chain transfer polymerization was applied to the synthesis of well-defined diblock glycopolymers carrying different cyclic carbohydrates on two blocks. The macroRAFT agents poly(methyl 6-O-methacryloyl-α-d-glucoside) dithiobenzoate and poly(2-methacryloxyethyl glucoside) were prepared by RAFT corresponding glycomonomers with (4-cyanopentanoic acid)-4-dithiobenzoate as agent. reactions stopped around 85% conversion in order preserve highest possible end-of-chain-functionality isolated precipitation methanol. Chain extension 2-methacryloxyethyl glucoside methyl 6-O-methacryloyl-α-d-mannoside afforded 6-O-methacryloyl-α-d-glucoside-block-2-methacryloxyethyl glucoside-block-methyl 6-O-methacryloyl-α-d-mannoside), respectively, having a predetermined molecular weight narrow polydispersity (PDI ≤ 1.20). The...