Impact of Hypothermia on the Response to Neuromuscular Blocking Drugs

作者: Tom Heier , James E. Caldwell , David C. Warltier

DOI: 10.1097/00000542-200605000-00025

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摘要: Muscle strength is reduced during hypothermia, both in the presence and absence of neuromuscular blocking drugs. A 2°C reduction body temperature may double duration blockade. Central muscle temperatures decline parallel, as long peripheral vasoconstriction does not occur. must be expected at a less than 36°C (corresponding to approximately 35°C). Local cooling hand make adductor pollicis twitch tension monitoring useful clinical anesthesia. The efficacy neostigmine maintained mild hypothermia. use nerve stimulator strongly recommended monitor effect drugs intraoperative

参考文章(86)
S. Agoston, J. M. K. H. Wierda, M. Belopavlovic, U. W. Kleef, P. J. Nederveen, A. M. Beaufort, THE INFLUENCE OF HYPOTHERMIA (SURFACE COOLING) ON THE TIME-COURSE OF ACTION AND ON THE PHARMACOKINETICS OF ROCURONIUM IN HUMANS European Journal of Anaesthesiology. ,vol. 12, pp. 95- 106 ,(1995)
Yoneda I, Aoki T, Okamoto T, Fukushima K, The effect of temperature on the action of several neuromuscular blocking agents in vitro Masui. The Japanese journal of anesthesiology. ,vol. 40, pp. 743- ,(1991)
Jean Cartaud, E. Lucio Benedetti, Michiki Kasai, Jean-Pierre Changeux, In vitro excitation of purified membrane fragments by cholinergic agonists The Journal of Membrane Biology. ,vol. 6, pp. 81- 88 ,(1971) , 10.1007/BF01874115
Thomas M. Hemmerling, François Donati, Neuromuscular blockade at the larynx, the diaphragm and the corrugator supercilii muscle: a review. Canadian Journal of Anaesthesia-journal Canadien D Anesthesie. ,vol. 50, pp. 779- 794 ,(2003) , 10.1007/BF03019373
S Agoston, J Ham, Rd Miller, F Vanderpol, Jf Crul, Lhdj Booij, Hypothermia and the pharmacokinetics and pharmacodynamics of pancuronium in the cat. Journal of Pharmacology and Experimental Therapeutics. ,vol. 207, pp. 532- 538 ,(1978)
W. J. Fawcett, A. Dash, G. A. Francis, J. B. Liban, J. N. Cashman, Recovery from neuromuscular blockade: residual curarisation following atracurium or vecuronium by bolus dosing or infusions Acta Anaesthesiologica Scandinavica. ,vol. 39, pp. 288- 293 ,(1995) , 10.1111/J.1399-6576.1995.TB04063.X
D. I. Sessler, E. H. Rubinstein, E. I. Eger, Core Temperature Changes during N2O Fentanyl and Halothane/O2 Anesthesia Anesthesiology. ,vol. 67, pp. 137- 138 ,(1987) , 10.1097/00000542-198707000-00032
C.J. HULL, PHARMACODYNAMICS OF NON-DEPOLARIZING NEUROMUSCULAR BLOCKING AGENTS BJA: British Journal of Anaesthesia. ,vol. 54, pp. 169- 182 ,(1982) , 10.1093/BJA/54.2.169
I. A. Boyd, A. R. Martin, The end-plate potential in mammalian muscle The Journal of Physiology. ,vol. 132, pp. 74- 91 ,(1956) , 10.1113/JPHYSIOL.1956.SP005503