Endothelial dysfunction and antioxidants.

摘要: The vascular endothelium plays a crucial role in the physiology of blood vessels and pathological processes atherosclerotic disease acute coronary syndromes. Endothelial dysfunction is core problem; it an impairment endothelium-dependent vasorelaxation caused by loss nitric oxide activity vessel wall, which results regulation homeostasis. Further understanding its mechanisms action possible therapeutic targets will be great importance. group antioxidant vitamins, A, C E, would seem uniquely situated to reduce cardiovascular events improving endothelial function reducing concentration reactive oxygen species wall preventing oxidative modification low-density lipoprotein. Unfortunately, despite extensive studies both observational randomized trials, weight evidence points little or no benefit from therapy.