Randomized, double-blind study in healthy adults to assess the boosting effect of Vaqta or Havrix after a single dose of Havrix.

摘要: A randomized, double-blind, multicenter study was conducted to investigate the boosting effect of Vaqta or Havrix in 537 healthy adults 18-53 years age who had received a single dose either 24 52 weeks earlier. Subjects were randomized 2 : 1 ratio receive for their second vaccine and followed clinical reactions 14 days after administered. Serum samples collected immediately before administered again 4 later evaluated hepatitis antibody (modified virus assay). The booster response rate administration similar (86.1% vs. 80.1% Havrix). geometric mean titers also similar: 3274 mIU/mL (95% confidence interval [CI], 2776-3858) versus 2423 CI, 1911-3074) Havrix. proportion subjects reported > =1 injection-site adverse experiences lower patients receiving than those (36.6% 59.7%; P<.001). results this indicate that regimen by is generally well tolerated highly immunogenic.