Pharmaceutics : the science of dosage form design

摘要: Design of dosage forms. PART ONE SCIENTIFIC PRINICIPLES OF FORMULATION SCIENCE Solutions and their properties. Rheology flow. Surface interfacial phenomena. Solubility dissolution rate. Disperse systems. Kinetics product stability. TWO PARTICLE AND POWDER TECHNOLOGY Solid-state properties powders. Particle size analysis. reduction. separation. Mixing. Powder THREE BIOPHARMACEUTICS PRINCIPLES DRUG DELIVERY Introduction to Biopharmaceutics. Factors influencing bioavailability. Assessment Dosage Regimens. Sustained extended release. FOUR DOSAGE FORM DESIGN MANUFACTURE Preformulation. Solutions, Suspensions Emulsions. Filtration. Powders granules. Granulation. Drying. Tablets compaction. Tablet coating. Capsules encapsulation. Pulmonary drug delivery. Nasal Rectal vaginal Parenteral products. Transdermal Delivery proteins/biotech Packs packaging. Materials fabrication corrosion. Heat transfer the steam. FIVE PHARMACEUTICAL MICROBIOLOGY STERILIZATION Fundamentals microbiology. The action physical chemical agents on micro-organisms. Microbiological contamination preservation. Principles sterilization. Sterilization practice. operation clean rooms.