Orally Active Vitamin D for Potential Chemoprevention of Posttransplant Malignancy

摘要: Posttransplant malignancy (PTM) is a limiting factor both for patient and allograft survival in kidney transplant recipients (KTRs). We hypothesized that active vitamin D compounds (AVD) could reduce PTM development KTRs. Ambulatory KTRs Japanese prospective cohort were followed from August 2007 to November 2010. The outcome of interest was newly diagnosed PTM. A propensity score (PS) having received AVDs estimated using 26 clinically relevant factors. used the Cox proportional hazards model with stratification by PS tertiles on assumption baseline hazard functions differ among tertiles. As sensitivity analyses, we inverse probability weighting matching. Among 218 participants, median age 50 (interquartile range [IQR], 40 59) years, 63.3% male, time since transplantation 11.2 (IQR, 5.2 17.1) mean GFR 41.3 (SD, 15.6) mL/min per 1.73 m(2). At baseline, 42.2% had been treated mainly glucocorticoid-induced osteoporosis. calcitriol (58.7%) alfacalcidol (41.3%). During follow-up, developed 5.4% 92 AVD users 8.7% 126 nonusers. Poor status common but serum 25-hydroxyvitamin level not significantly associated regression analysis. After stratifying patients tertiles, found lower risk (HR 0.25 [0.07 0.82]). Sensitivity analyses yielded similar results. are potential chemopreventive agents against