Short-term reorganization of input-deprived motor vibrissae representation following motor disconnection in adult rats.

摘要: It has been proposed that abnormal vibrissae input to the motor cortex (M1) mediates short-term cortical reorganization after facial nerve lesion. To test this hypothesis, we cut first infraorbital (ION cut) and then (VII in order evaluate M1 without any aberrant, facial-nerve-lesion-induced sensory feedback. In each animal, output was assessed both hemispheres by mapping movements induced intracortical microstimulation. compared different types of peripheral manipulations: (i) contralateral intact vibrissal pad (intact hemispheres), (ii) VII (iii) ION (iv) + (v) botulinum-toxin-injected BTX hemispheres). Right left untouched animals were reference for normal map (control Findings demonstrated that: (1) hemispheres, mean size representation not significantly from those control hemispheres; (2) movement clearly emerged only where had undergone disconnection hemispheres); (3) persistent loss did change pattern during 48 h paralysis Thus, paralysis, vibrissa does provide gating signal necessary trigger reorganization.