Developmental iron uptake and axonal transport in the retina of the rat
作者： T. Moos , N. Bernth , Y. Courtois , E.H. Morgan
DOI: 10.1016/J.MCN.2010.12.013
关键词:
摘要: Abstract We examined differently aged postnatal (P) rats for the distribution and uptake of iron in eye with main emphasis on retina. The concentration was 48 μg/g one day (P1). Then fell to approximately 12 μg/g at P30 rose 35 μg/g P70. Perls' stain which labels both ferrous ferric found exhibit a weak labeling retina P1 contrasted by robust macrophages choroid In older rats, cells much more intense confined widespread layers P16 adult injected intravenously [59Fe–125I]transferrin, 59Fe, estimated as volume distribution, significantly higher than that [125I]transferrin, compounds simultaneously [131I]albumin. rat, 59Fe expressed VD, linearly reaching 2500 nl 60 min. same magnitude. Comparing [125I]transferrin [131I]albumin eyeball Emulsion autoradiography retinas from [55Fe]transferrin into vitreous body showed mainly photoreceptor retinal ganglion cells. Adult [59Fe]transferrin anterograde axonal transport optic nerve, tract, superior colliculus. Immunoprecipitates homogenates nerve revealed precipitable an antibody raised against ferritin, indicative detachment transferrin within axons data demonstrate age-dependent but continuous retina, are
core.ac.uk
elsevier.com
sci-hub.se 参考文章(35)
Dunaief Jl, Rouault T, Hahn P, Dentchev T, Qian Y, Harris Zl, Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina Molecular Vision. ,vol. 10, pp. 598- 607 ,(2004)
Toichiro Kuwabara, Thomas A. Weidman, Development of the Rat Retina Investigative Ophthalmology & Visual Science. ,vol. 8, pp. 60- 69 ,(1969)
EH Morgan, H Huebers, CA Finch, Differences between the binding sites for iron binding and release in human and rat transferrin Blood. ,vol. 52, pp. 1219- 1228 ,(1978) , 10.1182/BLOOD.V52.6.1219.1219
J Nguyen-Legros, X Guillonneau, Y Courtois, C Sergeant, F Guillou, M G Yefimova, N Keller, J C Jeanny, Iron, ferritin, transferrin, and transferrin receptor in the adult rat retina. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 2343- 2351 ,(2000)
Tracey A. Rouault, Iron on the brain Nature Genetics. ,vol. 28, pp. 299- 300 ,(2001) , 10.1038/91036
Jean-Claude Jeanny, Xavier Guillonneau, Carole Beaumont, Yves Courtois, Claire Sergeant, Marina G. Yefimova, Nicole Keller, Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 537- 545 ,(2002)
Sixto García-Castiñeiras, Iron, the retina and the lens: a focused review. Experimental Eye Research. ,vol. 90, pp. 664- 678 ,(2010) , 10.1016/J.EXER.2010.03.003
Gregory Jon Anderson, Christopher D. Vulpe, Mammalian iron transport Cellular and Molecular Life Sciences. ,vol. 66, pp. 3241- 3261 ,(2009) , 10.1007/S00018-009-0051-1
Hitoshi Shichi, Microsomal electron transfer system of bovine retinal pigment epithelium Experimental Eye Research. ,vol. 8, pp. 60- 68 ,(1969) , 10.1016/S0014-4835(69)80081-3
Reiko Meguro, Yoshiya Asano, Hiroyasu Iwatsuki, Kazuhiko Shoumura, Perfusion-Perls and -Turnbull methods supplemented by DAB intensification for nonheme iron histochemistry: demonstration of the superior sensitivity of the methods in the liver, spleen, and stomach of the rat Histochemistry and Cell Biology. ,vol. 120, pp. 73- 82 ,(2003) , 10.1007/S00418-003-0539-Y