New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides.

摘要: A series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamide and furamide analogues were investigated in radioligand binding studies at adenosine receptor subtypes with an aim to obtain potent selective ligands. Benzamide linked thiazole was found be crucial for high affinity. The most compound indentified this study 5d low nanomolar affinity all four subtypes. Compounds 5a 5g showed moderate selectivity A2A receptors. Molecular docking versus human receptors combined membrane molecular dynamics performed rationalise the peculiar profile antagonist.