Involvement of Nuclear Factor κB in c-Myc Induction by Tubulin Polymerization Inhibitors
作者： V. Bourgarel-Rey , S. Vallee , O. Rimet , S. Champion , D. Braguer
关键词:
摘要: We showed previously that microtubule disassembly by vinblastine induces the proto-oncogene c-myc in epithelial mammary HBL100 cells ([Bourgarel-Rey et al., 2000][1]). In this study, we demonstrate treatment these cells, contrast to what was observed with colon adenocarcinoma cell line HT29-D4, activated transcription factor NFκB, which has been involved regulation. The also induced IκB degradation. Using transient transfection analysis, show trans -activation of decreased when NFκB binding sites on promoter were mutated. Additionally, dissolution -activated a thymidine kinase-CAT construct containing an site at −1180 −1080 bp relative P1 promoter. Thus, up-regulates enhancer activity site. These results suggest can -activate oncogene through NFκB. Taking into consideration paradoxical roles both and proliferation or apoptosis, data reveals complex action mechanism interfering agent. [1]: #ref-9
sci-hub.se 参考文章(43)
S. Manié, A. Schmid-Alliana, J. Kubar, B. Ferrua, B. Rossi, Disruption of microtubule network in human monocytes induces expression of interleukin-1 but not that of interleukin-6 nor tumor necrosis factor-alpha. Involvement of protein kinase A stimulation. Journal of Biological Chemistry. ,vol. 268, pp. 13675- 13681 ,(1993) , 10.1016/S0021-9258(19)38700-9
M.P. Duyao, D.J. Kessler, D.B. Spicer, C Bartholomew, J.L. Cleveland, M Siekevitz, G.E. Sonenshein, Transactivation of the c-myc promoter by human T cell leukemia virus type 1 tax is mediated by NF kappa B. Journal of Biological Chemistry. ,vol. 267, pp. 16288- 16291 ,(1992) , 10.1016/S0021-9258(18)41998-9
Martine Daujat, Sophie Charrasse, Isabelle Fabre, Pierre Lesca, Youssef Jounaidi, Christian Larroque, Lorenz Poellinger, Patrick Maurel, Induction of CYP1A1 Gene by Benzimidazole Derivatives During Caco‐2 Cell Differentiation FEBS Journal. ,vol. 237, pp. 642- 652 ,(1996) , 10.1111/J.1432-1033.1996.0642P.X
Gregory J. Kato, Chi V. Dang, Function of the c-Myc oncoprotein The FASEB Journal. ,vol. 6, pp. 3065- 3072 ,(1992) , 10.1096/FASEBJ.6.12.1521738
F M Botteri, K Ballmer-Hofer, B Rajput, Y Nagamine, Disruption of cytoskeletal structures results in the induction of the urokinase-type plasminogen activator gene expression. Journal of Biological Chemistry. ,vol. 265, pp. 13327- 13334 ,(1990) , 10.1016/S0021-9258(19)38302-4
M I Avigan, B Strober, D Levens, A far upstream element stimulates c-myc expression in undifferentiated leukemia cells. Journal of Biological Chemistry. ,vol. 265, pp. 18538- 18545 ,(1990) , 10.1016/S0021-9258(17)44785-5
L Ji, M Arcinas, L M Boxer, NF-kappa B sites function as positive regulators of expression of the translocated c-myc allele in Burkitt's lymphoma. Molecular and Cellular Biology. ,vol. 14, pp. 7967- 7974 ,(1994) , 10.1128/MCB.14.12.7967
Isabel Barasoain, José Manuel Andreu, Faustino Mollinedo, Consuelo Gajate, Induction of Apoptosis in Leukemic Cells by the Reversible Microtubule-disrupting Agent 2-Methoxy-5-(2′,3′,4′-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-one: Protection by Bcl-2 and Bcl-XL and Cell Cycle Arrest Cancer Research. ,vol. 60, pp. 2651- 2659 ,(2000)
R B Sartor, C Jobin, L Mayer, A Panja, S Haskill, Evidence for altered regulation of I kappa B alpha degradation in human colonic epithelial cells. Journal of Immunology. ,vol. 158, pp. 226- 234 ,(1997)
K J Riggs, S Saleque, K K Wong, K T Merrell, J S Lee, Y Shi, K Calame, Yin-yang 1 activates the c-myc promoter. Molecular and Cellular Biology. ,vol. 13, pp. 7487- 7495 ,(1993) , 10.1128/MCB.13.12.7487