Estrategia cubana de caracterización molecular del virus influenza A/H1N1pdm

作者: Vivian Kourí Cardellá , María Guadalupe Guzmán Tirado , Odalys Valdés Ramírez , Belsy Acosta Herrera , Alexander Piñón Ramos

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摘要: INTRODUCTION In April 2009, there was identified a variant of the A/H1N1 influenza virus swine origin, and shortly after first pandemic in XXI century declared. OBJECTIVES To establish nucleotide sequencing strategy for differential diagnosis seasonal A viruses, to obtain as much molecular information possible about hemagglutinin neuraminidase genes patients with influenza-like illnesses, those severe respiratory infection who died. METHODS Three strategies were designed implemented, which also offered important new Cuba. RESULTS The third provided most comprehensive results such diagnosis, surveillance D222G/E mutation Tamiflu-resistant H275Y viral variants. spite fact that mentioned mutations not detected, their presence Cuban population can be ignored since these this end. It is imperative design study fulfill objective. CONCLUSIONS our algorithm allowed characterization.

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