Neuromorphometric Measures as Endophenotypes of Schizophrenia Spectrum Disorders

摘要: Abnormal size of cortical and subcortical brain structures is strongly associated with schizophrenia, has also been reported in unaffected relatives patients, those diagnoses such as schizotypal personality disorder. Such volumetric measures have considered potential candidates for schizophrenia endophenotypes they are heritable, co-segregate the broadly defined neurocognitive behavioral phenotypes within first degree relatives, frequently present family members. In recent years, shape analyses become increasing interest due to their precisely locate surface defects increased sensitivity subtle volume changes. Statistical analysis variables recently shown improve discrimination individuals from healthy controls, when included overall volume. Computerized methods used detect systematic differences regional thickness gyral patterns between individuals. Methods large-deformation high-dimensional mapping spherical harmonics identified localized abnormalities hippocampus, thalamus basal ganglia which were similar observed siblings. The chapter reviews status current research involving both that applies discusses future directions required establish these endophenotypes.