Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle.

摘要: Data derived principally from peripheral tissues (fat, muscle and liver) show that insulin signals via diverse interconnecting intracellular pathways some of the major intersecting points (known as critical nodes) are IRSs (insulin receptor substrates), PI3K (phosphoinositide kinase)/Akt MAPK (mitogen-activated protein kinase). Most these probably also active in ovary their ability to interact with each other follicle-stimulating hormone (FSH) luteinizing (LH) signalling enables exert direct modulating influences on ovarian function. The present paper reviews actions uptake glucose by (granulosa, theca oocyte) during oestrous/menstrual cycle rodent, primate ruminant species. Insulin through discussed specific reference follicular cell types oocyte). for FSH granulosa cells LH summarized. roles insulin-mediated folliculogenesis discussed. It is suggested addition its well-established role providing energy cellular function may have functions cells, involving AMPK (AMP-dependent kinase) and/or hexosamine. Potential interactions or at nodes identified available evidence such Finally action insulin-sensitizing drugs metformin thiazolidinedione rosiglitazone reviewed.