Parathyroid cross-transplantation and development of high blood pressure in rats.

摘要: To clarify further the relationships between parathyroid glands and development of hypertension, we studied effect cross-transplantation these from young hypertensive rats in normotensive recipients. The were isolated 5-week-old Lyon (male female) Milan (only male) strains immediately grafted into corresponding, just parathyroidectomized same age. Control either sham-operated or with strain. Plasma calcium concentration decreased after parathyroidectomy (PTX) returned to near normal values 3 weeks graft. Systolic blood pressure increased slightly, but significantly, animals compared that control (mean increase, +9 mm Hg males; +5 females). In conclusion, gland transplantation strain is able chronically enhance animal. factor recently described may be implicated two strains. Our data extend observations obtained previously SHRs stroke-prone add evidence for a major function experimental hypertension.