Assessment of prevalence and load of torquetenovirus viraemia in a large cohort of healthy blood donors.

摘要: Abstract Objectives Torquetenovirus (TTV) is an emerging marker of functional immune competence with the potential to predict transplant-related adverse events. A large-scale epidemiological study was performed understand how basal values vary in healthy individuals according age and gender. Methods We tested plasma from 1017 blood donors aged 18–69 years. The presence load TTV were determined by a real-time PCR assay. sub-cohort 384 for anti-cytomegalovirus IgG antibodies, 100 participants also viraemia on paired whole sample. Results overall prevalence 65% (657/1017) mean (±SD) growth 5 ± 4% every 10 years increase, but stably higher males (465/690, 67%) than females (192/327, 59%). Mean 2.3 ± 0.7 Log copies/mL no sex difference. showed modest increases along 10-year intervals (mean ± SD: 0.3 ± 0.1). sampled 2 years later remained stable 2.3 ± 0.8 versus 2.2 ± 0.7 copies between samples). Twenty-six per cent (9/34) TTV-negative scored positive when tested, 1.4 ± 0.5 increase copy numbers tested. Conclusions This establishes value suggests that ageing causes only minimal viraemia.