Deficient activation of microglia during optic nerve degeneration
作者： Fanny Reichert , Shlomo Rotshenker
DOI: 10.1016/S0165-5728(96)00112-9
关键词:
摘要: Transection of an optic nerve (ON) is followed by slow removal myelin. We studied microglia for the expression molecules that characterize activated myelin phagocytosing macrophages: MAC-1, Fc gamma II/III receptor (FcR), MAC-2 and F4/80. In-vitro, expressed all phagocytosed In-vivo, intact ON displayed high levels little FcR F4/80, no MAC-2. The these was upregulated differentially in in-vivo degenerating ON: MAC-1 uniformly, F4/80 variably, sporadically. distribution correlated best with a pattern sporadic structural degeneration. Thus in-vivo, injury deficient activation, which we suggest contributes significantly to clearance
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