Regulation of Yeast NRD1 Expression by Premature Transcription Termination
作者： Kristina L. Carroll , Jessica M. Ames , Jeffry L. Corden , John T. Arigo
DOI: 10.1016/J.MOLCEL.2006.02.005
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摘要: Summary The yeast RNA binding proteins Nrd1 and Nab3 are required for termination of nonpolyadenylated transcripts from polymerase (Pol) II-transcribed snRNA snoRNA genes. In this paper, we show that NRD1 expression is regulated by Nrd1- Nab3-directed premature termination. Sequences recognized these present in mRNA expression. Chromatin immunoprecipitation transcription run-on experiments that, wild-type cells, Pol II occupancy high at the 5′ end gene decreases 3′ end. Mutation sites within leads to a relative increase downstream sequences. We further autoregulation involves components exosome newly discovered exosome-activating complex. Together, results eukaryotic cellular through
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