Neuropsychological syndromes associated with Alzheimer's/vascular dementia: a latent class analysis.

摘要: Background Epidemiologic autopsy studies show mixed Alzheimer's disease (AD)/vascular pathology in many patients. Moreover, clinical research shows that it is not uncommon for AD and vascular dementia (VaD) patients to be equally impaired on memory, executive, or other neurocognitive tests. However, this heterogeneity has been incorporated into the new diagnostic criteria (Dubois et al., 2010; McKhann 2011). Objective The current applied Latent Class Analysis (LCA) a protocol of six neuropsychological parameters identify phenotypic subtypes from large group AD/VaD participants. Follow-up analyses examined difference between groups neuroradiological measures process errors. Methods 223 were administered comprehensive protocol. Measures whole brain hippocampal volume available portion sample (n = 76). Results LCA identified four distinct groups: moderate/mixed 54; 24.21%), mild/mixed 91; 40.80%); dysexecutive 49, 21.97%), amnestic 29, 13.00%). comparing error scores showed exhibited difficulty sustaining mental set. evidenced pronounced impairment tests lexical retrieval/naming along with significant amnesia. Amnestic also presented gross amnesia, but relative sparing measures. Mild/mixed milder memory deficits intermediary groups. Conclusions There are profiles independent diagnosis, suggesting two wholly separate information should integrated paradigms.