Chronic Ethanol Treatment Reduces the Responsiveness of the Hypothalamic-Pituitary-Thyroid Axis to Central Stimulation
作者： R Thomas Zoeller , Donald L Fletcher , Agnes Simonyi , P Kevin Rudeen , None
DOI: 10.1111/J.1530-0277.1996.TB05277.X
关键词:
摘要: The hypothalamic-pituitary-thyroid (HPT) axis functions abnormally in man and animals chronically exposed to ethanol. most consistent observation humans is that the thyrotropin response thyrotropin-releasing hormone (TRH) blunted. We have tested hypothesis chronic ethanol treatment rats leads a diminished responsiveness of hypothalamus central stimulation. Animals were maintained on 1 3 diets for 4 weeks: (1) laboratory chow water provided ad libitum (chow-fed), (2) Sustacal chocolate liquid diet with vitamin mixture containing 5% (w/v) (ethanol), or (3) sucrose substituted isocalorically (35%) amounts matched weight-paired, ethanol-treated animal (pair-fed). At end weeks, evaluated their single injection (3 g/kg, ip) and/or exposure 5 degrees C. Chronic produced an increase TRH mRNA neurons paraventricular nucleus fully blocked thyrotropic cold exposure. However, did not exhibit altered basal levels triiodothyronine thyrotropin, nor they These data demonstrate alcohol alters functioning at least part by affecting nucleus.
sci-hub.se 参考文章(45)
Esteban Mezey, James J. Potter, Effects of thyroidectomy and triiodothyronine administration on rat liver alcohol dehydrogenase Gastroenterology. ,vol. 80, pp. 566- 574 ,(1981) , 10.1016/0016-5085(81)90020-2
Daphne D. Blumberg, [2] Creating a ribonuclease-free environment Methods in Enzymology. ,vol. 152, pp. 20- 24 ,(1987) , 10.1016/0076-6879(87)52005-5
J. A. ROMIJN, R. ADRIAANSE, G. BRABANT, K. PRANK, E. ENDERT, W. M. WIERSINGA, Pulsatile Secretion of Thyrotropin during Fasting: A Decrease of Thyrotropin Pulse Amplitude* The Journal of Clinical Endocrinology and Metabolism. ,vol. 70, pp. 1631- 1636 ,(1990) , 10.1210/JCEM-70-6-1631
N. G. Blake, M. R. Johnson, D. J. A. Eckland, O. J. F. Foster, S. L. Lightman, Effect of food deprivation and altered thyroid status on the hypothalamic-pituitary-thyroid axis in the rat. Journal of Endocrinology. ,vol. 133, pp. 183- 188 ,(1992) , 10.1677/JOE.0.1330183
K. J. Koller, R. S. Wolff, M. K. Warden, R. T. Zoeller, Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 7329- 7333 ,(1987) , 10.1073/PNAS.84.20.7329
James C. Garbutt, Joshua McDavid, George A. Mason, Dana Quade, Peter T. Loosen, Evidence for Normal Feedback Inhibition of Triiodothyronine on the Thyrotropin (TSH) Response to Thyrotropin‐Releasing Hormone (TRH) in Abstinent Male Alcoholics Alcoholism: Clinical and Experimental Research. ,vol. 16, pp. 881- 883 ,(1992) , 10.1111/J.1530-0277.1992.TB01886.X
Sandor Arancibia, Lucia Tapia-Arancibia, Ivan Assenmacher, Hélène Astier, Direct Evidence of Short-Term Cold-Induced TRH Release in the Median Eminence of Unanesthetized Rats Neuroendocrinology. ,vol. 37, pp. 225- 228 ,(1983) , 10.1159/000123547
R Thomas Zoeller, P Kevin Rudeen, None, Ethanol blocks the cold-induced increase in thyrotropin-releasing hormone mRNA in paraventricular nuclei but not the cold-induced increase in thyrotropin. Molecular Brain Research. ,vol. 13, pp. 321- 330 ,(1992) , 10.1016/0169-328X(92)90215-W
George A. Mason, Linda R. Noonan, James C. Garbutt, Jack D. Caldwell, Kazutaka Shimoda, Cheryl H. Walker, Li Li, Arthur J. Prange, Effects of Ethanol and Control Liquid Diets on the Hypothalamic-Pituitary-Thyroid Axis of Male Fischer-344 Rats Alcoholism: Clinical and Experimental Research. ,vol. 16, pp. 1130- 1137 ,(1992) , 10.1111/J.1530-0277.1992.TB00709.X
Jan M.M. Rondeel, Wim J. de Greef, Wim C.J. Hop, David L. Rowland, Theo J. Visser, Effect of cold exposure on the hypothalamic release of thyrotropin-releasing hormone and catecholamines. Neuroendocrinology. ,vol. 54, pp. 477- 481 ,(1991) , 10.1159/000125940