作者: DONALD W. KUNDEL , GEORGE BRECHER , GERALD P. BODEY , GEOFFREY M. BRITTIN
DOI: 10.1182/BLOOD.V23.4.526.526
关键词:
摘要: Reticulin fibrosis was found in 21 of 40 patients with acute lymphocytic leukemia when marrows were studied sequentially by Vim-Silverman needle biopsies. frequently occurred early the development disease. Mild degrees completely reversible remission, severe usually persisted, even through remissions. Fibrosis appeared to develop during relapse. Duration disease itself had little influence on degree reticulin fibrosis, and collagen seldom followed after many months’ duration. The prognosis their definitely poorer than for group without increased reticulin. virtually always prevented successful marrow biopsies standard technic aspiration. Bone necrosis 11 75 leukemia, but none 53 myelogenous life or at autopsy. major cause bone pain it associated marrow. infarcts not short survival all cases, general that demonstrable infarction.