Author Correction: The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

摘要: The Trapa japonica fruit is a natural plant growing in ponds with its roots the mud. It has long been used as home remedy for many diseases; however, major problem this kind of extract multicomponents-multitargets diseases. Such problems make it difficult to identify mechanism action. Another quality control and consistency. aim research was isolate single bioactive compound (peptide) derived from fruit. conducted various experimental techniques, such fermentation liquid chromatography, peptide. We isolated AC 2 peptide found be promising on human dermal papilla cells. Dihydrotestosterone (DHT) stresses cells cause hair loss resulting hormones environmental factors. purpose develop an understanding by which rescues dihydrotestosterone (DHT)-treated explored effects cell biological functions (HDPs). HDPs were treated DHT. Then, cytotoxicity assay, flow cytometry, Western blot, immunoprecipitation, 3D culture immunohistochemistry investigate mTORC1 pathway suppression autophagy apoptosis. In addition, we also synthesized AC2 alternative expensive isolation purification procedures confirmed potential biomedical applications. validated synthetic well purified established their similarity. Although extensive carried out extracts, few studies have separated (single compound).