NF-kappaB and rheumatic diseases.

摘要: NF-kappaB is an inducible transcription factor that controlled by the signal activation cascades. controls a number of genes involved in immuno-inflammatory responses, cell cycle progression, inhibition apoptosis, and adhesion, thus promoting chronic inflammatory responses. In fact, constitutively activated some rheumatic conditions such as rheumatoid arthritis (RA) systemic lupus erythematosus (SLE). Interestingly, anti-RA compounds have been shown to exhibit anti-NF-kappaB activities. addition, has linked carcinogenesis its constitutive demonstrated cancers leukemias. These findings substantiated long-standing proposal link among inflammation, autoimmunity, molecular terms. this review, I attempted overview pathologic involvement diseases discuss feasibility therapeutic strategy with signaling cascade novel targets.