Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats

摘要: Renal artery stenosis is frequently associated with resistant hypertension, which defined as failure to normalize blood pressure (BP) even when combined drugs are used. Inhibition of PDE5 by sildenafil has been shown increase endothelial function and decrease in experimental models. However, no available study evaluated the baroreflex sensitivity nor autonomic balance renovascular hypertensive rats treated sildenafil. In a translational medicine perspective, our hypothesis that could improve imbalance sensitivity, contributing lower pressure. Renovascular 2-kidney-1-clip (2K1C) sham were (45 mg/Kg/day) during 7 days. At end treatment, BP heart rate (HR) recorded conscious after 24-hour-recovery period. Spontaneous drug-induced tone evaluated; addition, lipid peroxidation was measured plasma samples. Treatment efficient increasing both spontaneous induced animals. also capable ameliorating 2K1C decreasing systemic oxidative stress. Taken together, these beneficial effects resulted significant reductions without affecting HR. We suggest be considered promising alternative treat hypertension.