Using single-particle ICP-MS for unravelling the effect of type of food on the physicochemical properties and gastrointestinal stability of ZnONPs released from packaging materials.

摘要: Abstract This article discusses the application of Single-Particle Inductively Coupled Plasma Mass Spectrometry (SP-ICP-MS) to study effect different types food (orange juice and chicken breast) on fate zinc oxide nanoparticles (ZnONPs) migrated from two widely employed packaging materials (polyethylene terephthalate (PET) low density polyethylene (LDPE)). The gastrointestinal stability ZnONPs was also evaluated. idea behind this is track for first time transformations underwent in steps their route consumer. presence high amount dissolved samples notably influenced size detection limit accuracy SP-ICP-MS measurements. diameter limits (LODd) were 26 nm, 95 nm, 108 nm 129 nm aqueous solution, breast extract oral intestinal extracts, respectively. characterization not possible with due below LODd. Besides difficulties, after extraction Tris-HCl allowed us determine that a 72% smaller than 95 nm. Complementary SP-ICP-MS, transmission electron microscopy (TEM) enabled detect small ( 200 nm) as ionic whereas case only