Immunological findings in neurological diseases associated with antibodies to HTLV-I: Activated lymphocytes in tropical spastic paraparesis

摘要: A retrovirus involvement in the etiology of certain neurological diseases is currently an area intense interest. Tropical spastic paraparesis and other chronic progressive myelopathies have been clearly associated with increased serum cerebrospinal fluid antibody titers to human T-lymphotropic virus type I; however, little known about cellular immune response. In present study, activated T-lymphocytes were found peripheral blood patients this disorder. There numbers large CD3-positive cells that also expressed histocompatibility leukocyte Class II (DR) interleukin 2-receptor molecules. addition, a significantly elevated spontaneous lymphoproliferative response was demonstrated all patients. This consistent vitro effects I. one patient, defect generation measles virus-specific cytotoxic T identified. These observations indicate abnormalities tropical paraparesis.